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2 edition of analysis and pharmacokinetics in dogs of diethyldithiocarbamate, a metabolite of disulfiram found in the catalog.

analysis and pharmacokinetics in dogs of diethyldithiocarbamate, a metabolite of disulfiram

John Cobby

analysis and pharmacokinetics in dogs of diethyldithiocarbamate, a metabolite of disulfiram

by John Cobby

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  • 31 Currently reading

Published by s.n.] in [Toronto .
Written in English

    Subjects:
  • Biopharmaceutics,
  • Drug metabolism,
  • Pharmacokinetics

  • Edition Notes

    ContributionsToronto, Ont. University.
    The Physical Object
    Paginationxii, 224 leaves :
    Number of Pages224
    ID Numbers
    Open LibraryOL19230605M

    Radojéié R. et al. The effect of diethyldithiocarbamate on antioxidant enzyme activities in the blood of rats The activity of GST in the plasma of rats treated with DDC was significantly higher (panalysis showed a significant positive correlation between GR and GST activities.   Oxazepam Pharmacokinetics Absorption Bioavailability. Readily absorbed from the GI tract, b with peak plasma concentration usually attained within about 3 hours. c Distribution Extent. Benzodiazepines are widely distributed into body tissues and cross the blood-brain barrier. b Oxazepam crosses the placenta. b d Benzodiazepines generally are distributed into milk. b Not known whether /

      A whole-body physiologically-based model was developed to describe the pharmacokinetics of the ansamycin benzoquinone antibiotic (allylamino)demethoxygeldanamycin (17AAG) and its active metabolite (amino)demethoxygeldanamycin (17AG) in blood, normal organs (lung, brain, heart, spleen, liver, kidney, skeletal muscle) and implanted human tumor Cited by: via a common metabolite, carbon disulfide(CS 2). CS 2 is known to induce distal peripheral neuropathy in laboratory animals. Although Na-dimethyldithiocarbamate may also be metabolized to carbon disulfide, days treatment of rats up to mg/kg/day with the chemical did not induce neuropathology. Ferbam has also not beenFile Size: KB.

    SCIentIfIC REPORTS ã DOIs 1 entificreports Synthesis-free PET imaging of brown adipose tissue and TSPO via combination of disulram and 64CuCl 2 Jing Yang1,2, Jian Yang1,3, Lu Wang4, Anna Moore1, Steven H. Liang 4 & Chongzhao Ran 1 PET imaging is a widely applicable but a very expensive technology. Drug testing and analysis Characterizing metabolites and potential metabolic pathways for the novel psychoactive substance methoxetamine. [E L Menzies, S C Hudson, P I Dargan, M C Parkin, D M Wood, A T Kicman] PMID


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Analysis and pharmacokinetics in dogs of diethyldithiocarbamate, a metabolite of disulfiram by John Cobby Download PDF EPUB FB2

Following the intravenous infusion of sodium diethyldithiocarbamate to dogs, the disposition kinetics of diethyldithiocarbamate (DDC), a metabolite of disulfiram, were assessed. Approximately 27% of Cited by:   S -Methyl N, N -diethyldithiocarbamate (MeDDC), a metabolite of the alcohol deterrent disulfiram, is converted to MeDDC sulfine and then S -methyl N, N -diethylthiocarbamate sulfoxide, the proposed active metabolite in vivo.

Several isoforms of CYP and to a lesser extent flavin monooxygenase (FMO) metabolize MeDDC in the liver. The human kidney contains FMO1 and Cited by: Disulfiram and its Metabolite, toxicology and pharmacokinetics of the title compounds. Recent findings regarding the ability of diethyldithiocarbamate (ditiocarb, Imuthiol®) to delay the progression of HN infections and AIDS, the discovery of its potential as a rescue agent in cancer chemotherapy, and the identification of disulfiram Cited by: Disulfiram and its Metabolite, Diethyldithiocarbamate: Pharmacology and status in the treatment of alcoholism, HIV infections, AIDS: Medicine & Health Science Books @ Male dogs were anesthesized and a drug solution of sodium diethyldithiocarbamate trihydrate was infused into the cephalic vein.

The disposition kinetics of diethyldithiocarbamate/a metabolite of disulfiram/ (DDC) were subsequently studied. The solutions contained mg/mL DDC anion. Diethyldithiocarbamate, an agent seemingly less toxic than aspirin, rivals it in the multiplicity and diversity of its pharmacological proper­ ties.

Notable among these are the manyfold potent immunostimulant effects, and though most of these involve effects on T -cells, the mechanism of diethyldithiocarbamate's action remains far from clear.

T1 - Catalysis of a disulfiram metabolite, S-methyl-N.N-diethyldithiocarbamate, by CYP and FMO3 in human liver microsomes AU - Pike, M. AU - Martin, Y. by: 1. Metabolism of a disulfiram metabolite, S-Methyl N,N-diethyldithiocarbamate, by flavin monooxygenase in human renal microsomes.

Drug Metabolism and Disposition. Feb 13;29(2) Pike, M. Gennett ; Mays, Dennis C. ; Macomber, David W. ; Lipsky, James J. / Metabolism of a disulfiram metabolite, S-Methyl N,N-diethyldithiocarbamate, by Cited by:   Abstract.

Two methods were used to detect sodium diethyldithiocarbamate (NaDEDC) in serum and urine. Gas liquid chromatography (GLC) was preferred for drug monitoring studies, while atomic absorption spectroscopy (AAS) was the method of Cited by: 1. Buy Disulfiram and its Metabolite, Diethyldithiocarbamate Softcover reprint of the original 1st ed.

by Peter K. Gessner (ISBN: ) from Amazon's Book Store. Everyday low prices and free delivery on eligible orders. Title:Diethyldithiocarbamate complex with copper: the mechanism of action in cancer cells VOLUME: 12 ISSUE: 12 Author(s):Zdenek Skrott and Boris Cvek Affiliation:Department of Cell Biology and Genetics, Faculty of Science, Palacky University, Slechtit Olomouc, Czech Republic Keywords:Breast cancer, Copper, Disulfiram, JAMM domain, by: Disulfiram acts by inhibiting the enzyme ALDH via its metabolite S-methyl N, N-diethyl-dithio-carbamate-sulphoxide [4, 5], leading to accumulation of acetaldehyde in blood.

This gives rise to. S-Methyl N,N-diethyldithiocarbamate (MeDDC), a metabolite of the alcohol deterrent disulfiram, is converted to MeDDC sulfine and then S-methyl N,N-diethylthiocarbamate sulfoxide, the proposed active metabolite in vivo. Several isoforms of CYP and to a lesser extent flavin monooxygenase (FMO) metabolize MeDDC in the by: Disulfiram is a drug used in the treatment of chronic alcoholism in man.

Accurate assessment of patient compliance is important in this treatment. This paper describes a method for the detection and quantitative analysis of diethylamine, a metabolite of disulfiram, in by: A derivative and possible physiological metabolite of disulfiram, diethyldithiocarbamic acid methanethiol mixed disulfide, is shown here for the first time to inactivate the mitochondrial low-Km.

Neuropeptides () 28, Pearson Professional Ltd I Peptide -Amidation: Differential Regulation by Disulfiram and Its Metabolite, Diethyldithiocarbamate G. MUELLER and M. ALTARAC Department of Physiology, Uniformed Services University of the Health Sciences, Jones Bridge Road, Bethesda, MarylandUSA (Reprint requests to GPM) Abstract--The rate limiting Cited by: 6.

Disulfiram and its reduced metabolite diethyldithiocarbamate have been identified previously as selective mechanism‐based inhibitors of human liver microsomal cytochrome P 2E1 in vitro. In animals, a single oral dose of disulfiram has been shown to produce a rapid and selective inactivation of hepatic P 2E1 content and catalytic Cited by: Radioactive and nonradioactive methods for the in vivo determination of disulfiram, diethyldithiocarbamate, and diethyldithiocarbamate-methyl ester.

Faiman MD, Dodd DE, Minor SS, Hanzlik R. Although disulfiram (tetraethylthiuram disulfide; DSF) has been used in the treatment of alcoholism for almost a quarter of a century, little is known about Cited by: Roles of FMO and CYP in the metabolism in human liver microsomes of S-methyl-N,N-diethyldithiocarbamate, a disulfiram metabolite M.

Gennett Pike, Yvette N. Martin, Dennis C. Mays, Linda M. Benson, Stephen Naylor, James J. LipskyCited by: 9. Intoxication with the alcohol-aversive drug disulfiram (Antabuse) and related dithiocarbamates may provoke neuropathies and, in some cases, damage the basal ganglia.

Rats received a single administration of disulfiram (7 and mg kg−1 i.p.) and equimolar doses (4 and mg kg−1 i.p.) of its metabolite diethyldithiocarbamate (DDC), roughly corresponding to the daily Cited by:.

Apparent t½s were calculated for disulfiram, diethyldithiocarbamate (DDTC), diethyldithiocarbamate‐methyl ester (DDTC‐Me), diethylamine (DEA), and carbon disulfide (CS 2) and were found to be, and hr. Elimination t½ for CS 2 in breath was hr. Average time to reach maximal plasma concentration after either Cited by:   The metabolism, excretion, and pharmacokinetics of S -allyl-l-cysteine (SAC), an active key component of garlic supplements, were examined in rats and dogs.

A single dose of SAC was administered orally or i.v. to rats (5 mg/kg) and dogs (2 mg/kg). SAC was well absorbed (bioavailability >90%) and its four metabolites— N -acetyl- S -allyl-l-cysteine (NAc-SAC), N -acetyl- S -allyl-l-cysteine Cited by: Diethyldithiocarbamate (DEDTC) is an active metabolite of clinically used drug disulfiram.

DEDTC is also widely used for its various types of mechanism of actions such as nuclear factor kappa-light-chain-enhancer of activated B-cells inhibition, superoxide dismutase (SOD1) inhibition, nitric oxide synthase inhibition, and also as thiol Cited by: 1.