3 edition of Uteroferrin : a mechanism of maternal to fetal iron transport in swine found in the catalog.
Written in English
|Statement||by Charles Andrew Ducsay.|
|The Physical Object|
|Pagination||xii, 180 leaves :|
|Number of Pages||180|
Wegger and Palludan () provided a more detailed description of the skeletal abnormalities during fetal development in swine resulting from maternal vitamin C deficiency. Ascorbic acid is also known to enhance absorption of iron from the intestine (Volker et al., ). Defects in iron absorption and utilization lead to iron deficiency and overload disorders. Adult mammals absorb iron through the duodenum, whereas embryos obtain iron through placental transport.
MILLER & ULLREY Uteroferrin, an Fe-containing, progesterone-induced glycoprotein, is inÂ volved in maternal-to-fetal Fe transport in swine (31). Intramuscular inÂ jections of Fe dextran in sows on three occasions in early to mid pregnancy had a positive effect on Fe in allantoic fluid of the conceptus, uteroferrin in placentae, and. To try and understand the mechanisms underlying this regulation, we carried out a series of studies altering maternal iron status midway through pregnancy. We measured iron levels in the maternal and fetal tissues and correlated the data to the expression of the proteins involved in the regulation of iron transfer and storage.
The secretion of uteroferrin (UF) is not responsive to the plasma levels of iron, thus it is speculated that the iron supply to the embryos during the peri-implantation period is determined by genotypes. Retinol-binding protein 4 (RBP4) is significantly . Transfer of iron across the placenta and fetal membranes in the rat. Am J Physiol –, Link | ISI Google Scholar; 14 Jaime-Perez JC, Herrera-Garza JL, and Gomez-Almaguer D. Sub-optimal fetal iron acquisition under a maternal environment. Arch Med Res –, Crossref | PubMed | ISI Google Scholar.
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Ducsay () has indicated the possible role of uteroferrin in maternal to fetal iron transport in swine. When the dam was provided with addi- tional iron during the period of peak movement of uteroferrin across the placenta, increases in both fetal iron stores and neonatal hemoglobin concentrations.
uteroferrin:amechanismofmaternalto fetalirontransportinswine by charlesandrewducsay adissertationpresentedtothegraduatecouncil oftheuniversityoffloridainpartial. Uteroferrin: a mechanism of maternal to fetal iron transport in swine / By Charles Andrew Ducsay Topics: Animal Science, Animal Science thesis : Charles Andrew Ducsay.
Transferrin is an iron transport protein in the pig fetus and is important (along with uteroferrin) in supplying this mineral to developing erythropoietic and other tissues. Uteroferrin: a mechanism of maternal to fetal iron transport in swine / by Charles Andrew Ducsay.
By Charles Andrew Ducsay Topics: Animal Science, Animal Science thesis : Charles Andrew Ducsay. UTEROFERRIN: A MECHANISM OF MATERNAL TO FETAL IRON TRANSPORT IN SWINE By Charles Andrew Ducsay December Chairman: Dr. Fuller W. Bazer Major Department: Animal Science Uteroferrin (UF) is an iron-containing, progesterone-induced glycoprotein with an approximate molecular weight of 35, This protein is present in uterine secretions.
Uteroferrin (UF) is an iron-containing, progesterone-induced glycoprotein present in allantoic fluid and uterine secretions of swine between Days 30 and of gestation. The role of UF in. Uteroferrin (UF) is a progesterone-induced acid phosphatase produced by uterine glandular epithelia in mammals during pregnancy and targeted to sites of hematopoiesis throughout pregnancy.
Uteroferrin, a progesterone-induced glycoprotein containing two molecules of iron, is secreted by the uterine endometrial epithelium of pigs. The role of uteroferrin is to transport iron from the uterine endometrial glands to the fetal–placental unit, and there is evidence that it stimulates hematopoiesis (Bazer et al., ; Ying et al., ).
View chapter Purchase book Gametogenesis, Fertilization and Early Development. Iron transport via the secretion of uteroferrin is the prototype for the transport of small molecules by endometrial protein secretion in the pig. Secretion of this protein by the endometrium occurs in a biphasic pattern, with increases occurring between Days 10 and 13 and between Days 20 and 40 of gestation [ 24, 25, 29 – 31 ].
Moreover, the localization pattern of ir-RBP is strikingly similar to that of uteroferrin, a kDa glycoprotein that functions as an iron transporter to the developing porcine conceptus [42, 43], and iron, complexed to uteroferrin in uterine glands, is secreted into the areolar cavity [40, 42–46].
The similar staining and secretion patterns. REVIEW Open Access Placental accommodations for transport and metabolism during intra-uterine crowding in pigs Jeffrey L Vallet*, Anthony K McNeel, Jeremy R Miles and Bradley A Freking Abstract Litter size and birth weights are limited by uterine capacity, defined as the ability of.
MECHANISMS OF IRON TRANSPORT. Several ways of maternal-fetal iron transfer are reported such as: uterine secretions, direct transfer of iron in the serum through membranes of chorioallantoic placenta and phagocytosis of red blood cells extravased by trophoblast in the interior of hemophagous organs, or hematoma followed by releasing of iron.
Among these nutrients, uteroferrin, an iron-transporting acid phosphatase, is an important aspect of fetal iron supply. It has been studied extensively (see also above) and arises from the areolar region of the endometrium (Dantzer & Nielsen, ).
The uteroferrin also acts as a protein which function is transportation of iron, going to the fetal surface in different forms of ferritin or ferric ferrocyanide. The uteroferrin is the returned to the maternal circulation having left the iron at the receptors of the trophoblastic cells.
The concentrations of all four amino acids in maternal and fetal plasma throughout gestation are consistent with passive transport as the mechanism of transport (fetal concentration is lower than maternal).
If the high expression of the gene is related to the essential nature of the amino acids and the passivity of transport, it suggests that. However, the complex interactions of maternal and embryo/fetal factors and their effects on the uterine environment are far from understood.
Therefore, to gain a better understanding of maternal-embryo/fetal communication, studies were undertaken to elucidate the complex mechanisms regulating the uterine expression of porcine SLPI and porcine UF.
Uteroferrin functions to transport iron to the fetus (Roberts & Bazer ), which is considered essential for normal fetal development. However, iron-containing proteins catalyze lipid peroxidation in the presence of H 2 O 2 and ascorbic acid (MinottiVallet ). Association between Uteroferrin, Retinol-Binding Protein, and Transferrin within teins may be to protect maternal and fetal tissues from lipid peroxidation that is a possible consequence of iron transport via endometrial secretion of UF.
INTRODUCTION During pregnancy in. Maternal undernutrition or overnutrition during gestation reduces fetal growth in both humans and experimental animals.
1, 3, 13, Animal studies have revealed complex biological mechanisms responsible for IUGR. 3 These mechanisms have been corroborated with clinical observations and include: (1) reduced placental growth and vascularity.CA Ducsay, WC Buhi, FW Bazer, RM Roberts, and GE Combs.
Role of uteroferrin in placental iron transport: effect of maternal iron treatment on fetal iron and uteroferrin content and neonatal hemoglobin. J Anim Sci – Google Scholar.Role of uteroferrin in placental iron transport in swine: relationship between uteroferrin levels and iron deposition in the conceptus during gestation.
Fetal–maternal interactions during the establishment of pregnancy in ruminants. Impacts of amino-acid nutrition on pregnancy outcome in pigs: mechanisms and implications for swine.